MOUNTING INTEREST IS RECENTLY EXPRESSED FOR SURFACE FUNCTIONALIZATION OF NANOCATALYSTS IN WHICH THE NANOSCALE ARCHITECTURE OF ACTIVE CENTERS PLAYS A DOMINANT ROLE IN DETERMINING THEIR EFFICIENCY AND SELECTIVITY [1-2]. SURFACE FUNCTIONALIZED IRON OXIDE MAGNETIC NANOPARTICLES (MNPS) ARE A KIND OF NOVEL FUNCTIONAL MATERIALS, WHICH HAVE BEEN WIDELY USED IN BIOTECHNOLOGY AND CATALYSIS [3-4]. GOOD BIOCOMPATIBILITY AND BIODEGRADABILITY AS WELL AS BASIC MAGNETIC CHARACTERISTICS COULD BE DENOTED FOR FUNCTIONAL ORGANIC MATERIALS GRAFTED TO MNPS. MAGNETIC NANOCATALYSTS CAN EASILY BE SEPARATED AND RECYCLED FROM THE PRODUCTS BY AN EXTERNAL MAGNET. MOREOVER, THEIR CATALYTIC PERFORMANCE IS ENHANCED, FOR THE AVAILABLE SURFACE AREA OF THE NONPOROUS MNPS IS EXTERNAL AND THE INTERNAL DIFFUSION IS PRACTICALLY AVOIDED. THE SILANE AGENTS SUCH AS 3-AMINOPROPYLTRIETHYLOXYSILANE (APTES) AND MERCAPTOPROPYLTRIETHOXYSILANE (MPTES) ARE OFTEN CONSIDERED AS POTENTIAL CANDIDATES FOR MODIFYING THE SURFACE OF MNPS DIRECTLY. SUCH SURFACE MODIFICATION ENHANCES THE BIOCOMPATIBILITY AND PROVIDES RATHER HIGH DENSITY SURFACE FUNCTIONAL END GROUPS WHICH ALLOW FOR CONNECTING TO OTHER METALS, POLYMERS OR BIOMOLECULES [5].IN THIS REPORT, A NOVEL ORGANIC–INORGANIC HYBRID HETEROGENEOUS CATALYST (SA-MNPS) WAS SYNTHESIZED BY ANCHORING CHLOROSULFURIC ACID ON AMINO-MODIFIED MAGNETIC FE3O4 NANOPARTICLES. CHARACTERIZATION OF THE FUNCTIONALIZED MAGNETIC NANOPARTICLES BY XRD, FT-IR, TGA, AND TEM DEMONSTRATED THE SUCCESSFUL GRAFTING OF SULFAMIC ACID INTO THE AMINO-FUNCTIONALIZED FE3O4 NANOPARTICLES. THE ACETYLATION OF VARIOUS ALCOHOLS BY ACETIC ANHYDRIDE OVER THE SA-MNPS CATALYST RESULTED IN HIGH TO EXCELLENT YIELDS, UNDER SOLVENT-FREE CONDITIONS AT ROOM TEMPERATURE. THE HETEROGENEOUS CATALYST COULD BE RECOVERED EASILY AND REUSED MANY TIMES WITHOUT SIGNIFICANT LOSS OF ITS CATALYTIC ACTIVITY.

THERE HAS SPECIAL INTEREST IN THE CHEMISTRY OF PERIMIDINES DUE TO A WIDE RANGE OF BIOLOGICAL ACTIVITIES EXHIBITED BY THESE COMPOUNDS [1]. THE GENERAL METHOD FOR THE SYNTHESIS OF PERIMIDINES INVOLVES THE CONDENSATION REACTION OF 1, 8-DIAMINONAPHTHALENE WITH A CARBONYL GROUP IN THE PRESENCE OF A LEWIS OR MINERAL ACID. SEVERAL METHODS FOR SYNTHESIS OF PERIMIDINES HAVE BEEN REPORTED. HOWEVER, IN SPITE OF THEIR POTENTIAL UTILITY, MANY OF THESE METHODS ARE ASSOCIATED WITH SOME LIMITATIONS AND GENERALLY NEED STRONG ACIDIC CONDITIONS, EXPENSIVE OR NON-AVAILABLE REAGENTS, PROLONGED REACTION TIMES AND HIGH TEMPERATURES. THUS, THE INTRODUCTION OF NEW METHODS OR FURTHER WORK ON TECHNICAL IMPROVEMENTS TO OVERCOME THESE LIMITATIONS IS STILL NEEDED.SULFAMIC ACID (NH2SO3H) HAS EMERGED AS A PROMISING SUBSTANCE FOR CONVENTIONAL BRONSTED AND LEWIS ACID CATALYSTS. IT HAS DISPLAYS AN EXCELLENT ACTIVITY OVER A VAST ARRAY OF ACID CATALYZED ORGANIC TRANSFORMATIONS [2, 3]. FOR UNIQUE CATALYST FEATURES OF SULFAMIC ACID (SA) AND ALSO DUE TO CONTINUATION OF OUR STUDIES ON GREEN SYNTHESIS OF HETEROCYCLIC COMPOUNDS [4], WE WISH TO REPORT A SIMPLE AND EFFICIENT ONE POT PRACTICAL METHOD FOR THE SYNTHESIS OF PERIMIDINES BY REACTION OF 1, 8-DIAMINONAPHTHALENE AND ALDEHYDES IN THE PRESENCE OF SULFAMIC ACID. SIMPLE OPERATIONS, SHORT REACTION TIME, ENVIRONMENTAL COMPATIBILITY, AVAILABILITY AND REUSABILITY OF CATALYST, AND MILD REACTION CONDITIONS ARE KEY FEATURES OF THIS NEW PROTOCOL.

MOUNTING INTEREST IS RECENTLY EXPRESSED FOR SURFACE FUNCTIONALIZATION OF NANOCATALYSTS IN WHICH THE NANOSCALE ARCHITECTURE OF ACTIVE CENTERS PLAYS A DOMINANT ROLE IN DETERMINING THEIR EFFICIENCY AND SELECTIVITY [1-2]. SURFACE FUNCTIONALIZED IRON OXIDE MAGNETIC NANOPARTICLES (MNPS) ARE A KIND OF NOVEL FUNCTIONAL MATERIALS, WHICH HAVE BEEN WIDELY USED IN BIOTECHNOLOGY AND CATALYSIS [3-4]. GOOD BIOCOMPATIBILITY AND BIODEGRADABILITY AS WELL AS BASIC MAGNETIC CHARACTERISTICS COULD BE DENOTED FOR FUNCTIONAL ORGANIC MATERIALS GRAFTED TO MNPS. MAGNETIC NANOCATALYSTS CAN EASILY BE SEPARATED AND RECYCLED FROM THE PRODUCTS BY AN EXTERNAL MAGNET. MOREOVER, THEIR CATALYTIC PERFORMANCE IS ENHANCED, FOR THE AVAILABLE SURFACE AREA OF THE NONPOROUS MNPS IS EXTERNAL AND THE INTERNAL DIFFUSION IS PRACTICALLY AVOIDED. THE SILANE AGENTS SUCH AS 3-AMINOPROPYLTRIETHYLOXYSILANE (APTES) AND MERCAPTOPROPYLTRIETHOXYSILANE (MPTES) ARE OFTEN CONSIDERED AS POTENTIAL CANDIDATES FOR MODIFYING THE SURFACE OF MNPS DIRECTLY. SUCH SURFACE MODIFICATION ENHANCES THE BIOCOMPATIBILITY AND PROVIDES RATHER HIGH DENSITY SURFACE FUNCTIONAL ENDGROUPS WHICH ALLOW FOR CONNECTING TO OTHER METALS, POLYMERS OR BIOMOLECULES [5].IN THIS REPORT, A NOVEL ORGANIC–INORGANIC HYBRID HETEROGENEOUS CATALYST (SA-MNPS) WAS SYNTHESIZED BY ANCHORING CHLOROSULFURIC ACID ON AMINO-MODIFIED MAGNETIC FE3O4 NANOPARTICLES. CHARACTERIZATION OF THE FUNCTIONALIZED MAGNETIC NANOPARTICLES BY XRD, FTIR, TGA, AND TEM DEMONSTRATED THE SUCCESSFUL GRAFTING OF SULFAMIC ACID INTO THE AMINOFUNCTIONALIZED FE3O4 NANOPARTICLES. THE MANY ORGANIC TRANSFORMATION REACTIONS OVER THE SA-MNPS CATALYST RESULTED IN HIGH TO EXCELLENT YIELDS, UNDER SOLVENT-FREE CONDITIONS AT ROOM TEMPERATURE. THE HETEROGENEOUS CATALYST COULD BE RECOVERED EASILY AND REUSED MANY TIMES WITHOUT SIGNIFICANT LOSS OF ITS CATALYTIC ACTIVITY.

COMPOUNDS CONTAINING 1, 3-AMINO OXYGENATED FUNCTIONAL GROUPS SUCH AS 1-AMIDOALKYL-2-NAPHTHOL DERIVATIVES FREQUENTLY FOUND IN VARIETY BIOLOGICALLY ACTIVE NATURAL PRODUCTS AND POTENT DRUGS SUCH AS A NUMBER OF NUCLEOSIDE ANTIBIOTICS AND HIV PROTEASE INHIBITORS [1, 2]...